Enhancing gene editing specificity by attenuating DNA cleavage kinetics
Enhancing gene editing specificity by attenuating DNA cleavage kinetics
About this item
Full title
Author / Creator
Miller, Jeffrey C. , Patil, Deepak P. , Xia, Danny F. , Paine, Charles B. , Fauser, Friedrich , Richards, Hunter W. , Shivak, David A. , Bendaña, Yuri R. , Hinkley, Sarah J. , Scarlott, Nicholas A. , Lam, Stephen C. , Reik, Andreas , Zhou, Yuanyue , Paschon, David E. , Li, Patrick , Wangzor, Tenzin , Lee, Gary , Zhang, Lei and Rebar, Edward J.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Engineered nucleases have gained broad appeal for their ability to mediate highly efficient genome editing. However the specificity of these reagents remains a concern, especially for therapeutic applications, given the potential mutagenic consequences of off-target cleavage. Here we have developed an approach for improving the specificity of zinc...
Alternative Titles
Full title
Enhancing gene editing specificity by attenuating DNA cleavage kinetics
Authors, Artists and Contributors
Author / Creator
Patil, Deepak P.
Xia, Danny F.
Paine, Charles B.
Fauser, Friedrich
Richards, Hunter W.
Shivak, David A.
Bendaña, Yuri R.
Hinkley, Sarah J.
Scarlott, Nicholas A.
Lam, Stephen C.
Reik, Andreas
Zhou, Yuanyue
Paschon, David E.
Li, Patrick
Wangzor, Tenzin
Lee, Gary
Zhang, Lei
Rebar, Edward J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2267028296
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2267028296
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/s41587-019-0186-z
