Renin cells with defective Gsα/cAMP signaling contribute to renal endothelial damage
Renin cells with defective Gsα/cAMP signaling contribute to renal endothelial damage
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Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
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Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
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Contents
Synthesis of renin in renal renin-producing cells (RPCs) is controlled via the intracellular messenger cAMP. Interference with cAMP-mediated signaling by inducible knockout of Gs-alpha (Gsα) in RPCs of adult mice resulted in a complex adverse kidney phenotype. Therein, glomerular endothelial damage was most striking. In this study, we investigated...
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Full title
Renin cells with defective Gsα/cAMP signaling contribute to renal endothelial damage
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TN_cdi_proquest_miscellaneous_2269394681
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2269394681
Other Identifiers
ISSN
0031-6768
E-ISSN
1432-2013
DOI
10.1007/s00424-019-02298-9
