Structural basis of assembly of the human T cell receptor–CD3 complex
Structural basis of assembly of the human T cell receptor–CD3 complex
About this item
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Author / Creator
Dong, De , Zheng, Lvqin , Lin, Jianquan , Zhang, Bailing , Zhu, Yuwei , Li, Ningning , Xie, Shuangyu , Wang, Yuhang , Gao, Ning and Huang, Zhiwei
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The αβ T cell receptor (TCR), in association with the CD3γε–CD3δε–CD3ζζ signalling hexamer, is the primary determinant of T cell development and activation, and of immune responses to foreign antigens. The mechanism of assembly of the TCR–CD3 complex remains unknown. Here we report a cryo-electron microscopy structure of human TCRαβ in complex with...
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Full title
Structural basis of assembly of the human T cell receptor–CD3 complex
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Record Identifier
TN_cdi_proquest_miscellaneous_2282451160
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2282451160
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1537-0
