Structure and mechanogating of the mammalian tactile channel PIEZO2
Structure and mechanogating of the mammalian tactile channel PIEZO2
About this item
Full title
Author / Creator
Wang, Li , Zhou, Heng , Zhang, Mingmin , Liu, Wenhao , Deng, Tuan , Zhao, Qiancheng , Li, Yiran , Lei, Jianlin , Li, Xueming and Xiao, Bailong
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
PIEZO2 is a mechanosensitive cation channel that has a key role in sensing touch, tactile pain, breathing and blood pressure. Here we describe the cryo-electron microscopy structure of mouse PIEZO2, which is a three-bladed, propeller-like trimer that comprises 114 transmembrane helices (38 per protomer). Transmembrane helices 1–36 (TM1–36) are fold...
Alternative Titles
Full title
Structure and mechanogating of the mammalian tactile channel PIEZO2
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2288010732
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2288010732
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1505-8
