Evolution of a reverse transcriptase to map N1-methyladenosine in human messenger RNA
Evolution of a reverse transcriptase to map N1-methyladenosine in human messenger RNA
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Chemical modifications to messenger RNA are increasingly recognized as a critical regulatory layer in the flow of genetic information, but quantitative tools to monitor RNA modifications in a whole-transcriptome and site-specific manner are lacking. Here we describe a versatile platform for directed evolution that rapidly selects for reverse transc...
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Full title
Evolution of a reverse transcriptase to map N1-methyladenosine in human messenger RNA
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TN_cdi_proquest_miscellaneous_2296658745
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2296658745
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ISSN
1548-7091
E-ISSN
1548-7105
DOI
10.1038/s41592-019-0550-4
