The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequ...
The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies
About this item
Full title
Author / Creator
Angus, Lindsay , Smid, Marcel , Wilting, Saskia M. , van Riet, Job , Van Hoeck, Arne , Nguyen, Luan , Nik-Zainal, Serena , Steenbruggen, Tessa G. , Tjan-Heijnen, Vivianne C. G. , Labots, Mariette , van Riel, Johanna M. G. H. , Bloemendal, Haiko J. , Steeghs, Neeltje , Lolkema, Martijn P. , Voest, Emile E. , van de Werken, Harmen J. G. , Jager, Agnes , Cuppen, Edwin , Sleijfer, Stefan and Martens, John W. M.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The whole-genome sequencing of prospectively collected tissue biopsies from 442 patients with metastatic breast cancer reveals that, compared to primary breast cancer, tumor mutational burden doubles, the relative contributions of mutational signatures shift and the mutation frequency of six known driver genes increases in metastatic breast cancer....
Alternative Titles
Full title
The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies
Authors, Artists and Contributors
Author / Creator
Smid, Marcel
Wilting, Saskia M.
van Riet, Job
Van Hoeck, Arne
Nguyen, Luan
Nik-Zainal, Serena
Steenbruggen, Tessa G.
Tjan-Heijnen, Vivianne C. G.
Labots, Mariette
van Riel, Johanna M. G. H.
Bloemendal, Haiko J.
Steeghs, Neeltje
Lolkema, Martijn P.
Voest, Emile E.
van de Werken, Harmen J. G.
Jager, Agnes
Cuppen, Edwin
Sleijfer, Stefan
Martens, John W. M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2299768824
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2299768824
Other Identifiers
ISSN
1061-4036,1546-1718
E-ISSN
1546-1718
DOI
10.1038/s41588-019-0507-7
