Identification of actinomycin D as a specific inhibitor of the alternative pathway of peptidoglycan...
Identification of actinomycin D as a specific inhibitor of the alternative pathway of peptidoglycan biosynthesis
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Peptidoglycan is an indispensable component of bacterial cell walls. We recently discovered an alternative peptidoglycan biosynthetic pathway, which involves two enzymes, MurD2 and MurL, catalyzing the ligation of
l
-Glu to UDP-MurNAc-
l
-Ala and epimerization of the terminal
l
-Glu of the MurD2 product, respectively. Because the...
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Full title
Identification of actinomycin D as a specific inhibitor of the alternative pathway of peptidoglycan biosynthesis
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TN_cdi_proquest_miscellaneous_2309501075
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2309501075
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ISSN
0021-8820
E-ISSN
1881-1469
DOI
10.1038/s41429-019-0252-2
