Enhancement of FK520 production in Streptomyces hygroscopicus by combining traditional mutagenesis w...
Enhancement of FK520 production in Streptomyces hygroscopicus by combining traditional mutagenesis with metabolic engineering
About this item
Full title
Author / Creator
Yu, Zhituo , Lv, Huihui , Wu, Yuanjie , Wei, Tengyun , Yang, Songbai , Ju, Dianwen and Chen, Shaoxin
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
FK520 (ascomycin), a 23-membered macrolide with immunosuppressive activity, is produced by
Streptomyces hygroscopicus
. The problem of low yield and high impurities (mainly FK523) limits the industrialized production of FK520. In this study, the FK520 yield was significantly improved by strain mutagenesis and genetic engineering. First, a FK5...
Alternative Titles
Full title
Enhancement of FK520 production in Streptomyces hygroscopicus by combining traditional mutagenesis with metabolic engineering
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2314007317
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2314007317
Other Identifiers
ISSN
0175-7598
E-ISSN
1432-0614
DOI
10.1007/s00253-019-10192-8
