On-chip 3D neuromuscular model for drug screening and precision medicine in neuromuscular disease
On-chip 3D neuromuscular model for drug screening and precision medicine in neuromuscular disease
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
This protocol describes the design, fabrication and use of a 3D physiological and pathophysiological motor unit model consisting of motor neurons coupled to skeletal muscles interacting via the neuromuscular junction (NMJ) within a microfluidic device. This model facilitates imaging and quantitative functional assessment. The ‘NMJ chip’ enables rea...
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Full title
On-chip 3D neuromuscular model for drug screening and precision medicine in neuromuscular disease
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TN_cdi_proquest_miscellaneous_2338081775
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2338081775
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ISSN
1754-2189
E-ISSN
1750-2799
DOI
10.1038/s41596-019-0248-1
