Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the agin...
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
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Author / Creator
Marschallinger, Julia , Iram, Tal , Zardeneta, Macy , Lee, Song E. , Lehallier, Benoit , Haney, Michael S. , Pluvinage, John V. , Mathur, Vidhu , Hahn, Oliver , Morgens, David W. , Kim, Justin , Tevini, Julia , Felder, Thomas K. , Wolinski, Heimo , Bertozzi, Carolyn R. , Bassik, Michael C. , Aigner, Ludwig and Wyss-Coray, Tony
Publisher
New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Contents
Microglia become progressively activated and seemingly dysfunctional with age, and genetic studies have linked these cells to the pathogenesis of a growing number of neurodegenerative diseases. Here we report a striking buildup of lipid droplets in microglia with aging in mouse and human brains. These cells, which we call ‘lipid-droplet-accumulatin...
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Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
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TN_cdi_proquest_miscellaneous_2343051964
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2343051964
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/s41593-019-0566-1
