Interleukin-23 engineering improves CAR T cell function in solid tumors
Interleukin-23 engineering improves CAR T cell function in solid tumors
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Cytokines that stimulate T cell proliferation, such as interleukin (IL)-15, have been explored as a means of boosting the antitumor activity of chimeric antigen receptor (CAR) T cells. However, constitutive cytokine signaling in T cells and activation of bystander cells may cause toxicity. IL-23 is a two-subunit cytokine known to promote proliferat...
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Full title
Interleukin-23 engineering improves CAR T cell function in solid tumors
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TN_cdi_proquest_miscellaneous_2350904613
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2350904613
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ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/s41587-019-0398-2
