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Targeted sensitization of tumor cells for radiation through monocarboxylate transporters 1 and 4 inh...

Targeted sensitization of tumor cells for radiation through monocarboxylate transporters 1 and 4 inh...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2409641983

Targeted sensitization of tumor cells for radiation through monocarboxylate transporters 1 and 4 inhibition in vitro

About this item

Full title

Targeted sensitization of tumor cells for radiation through monocarboxylate transporters 1 and 4 inhibition in vitro

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Journal title

Clinical oral investigations, 2021-01, Vol.25 (1), p.295-310

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

More information

Scope and Contents

Contents

Objectives
Monocarboxylate transporters (MCT) 1, 2 and 4 play an important role in tumor metabolism. The amount of lactate transported by MCT’s highly correlates with overall survival. Furthermore, glycolysis and hypoxia are possible causes for radiation resistance.
Materials and methods
An oral squamous cell carcinoma cell line (CAL27, AT...

Alternative Titles

Full title

Targeted sensitization of tumor cells for radiation through monocarboxylate transporters 1 and 4 inhibition in vitro

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2409641983

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2409641983

Other Identifiers

ISSN

1432-6981

E-ISSN

1436-3771

DOI

10.1007/s00784-020-03364-8

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