Leveraging preclinical models for the development of Alzheimer disease therapeutics
Leveraging preclinical models for the development of Alzheimer disease therapeutics
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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A large number of mouse models have been engineered, characterized and used to advance biomedical research in Alzheimer disease (AD). Early models simply damaged the rodent brain through toxins or lesions. Later, the spread of genetic engineering technology enabled investigators to develop models of familial AD by overexpressing human genes such as...
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Full title
Leveraging preclinical models for the development of Alzheimer disease therapeutics
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TN_cdi_proquest_miscellaneous_2419712504
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2419712504
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ISSN
1474-1776
E-ISSN
1474-1784
DOI
10.1038/s41573-020-0065-9
