PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome
PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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EZH1 and EZH2 are enzymatic components of polycomb repressive complex (PRC) 2, which catalyzes histone H3K27 tri-methylation (H3K27me3) to repress the transcription of PRC2 target genes. We previously reported that the hematopoietic cell-specific
Ezh2
deletion (
Ezh2
Δ/Δ
) induced a myelodysplastic syndrome (MDS)-like disease in mice...
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PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome
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TN_cdi_proquest_miscellaneous_2436395927
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2436395927
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ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/s41375-020-01023-1
