Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD
Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Mutation of
C9orf72
is the most prevalent defect associated with amyotrophic lateral sclerosis and frontotemporal degeneration
1
. Together with hexanucleotide-repeat expansion
2
,
3
, haploinsufficiency of
C9orf72
contributes to neuronal dysfunction
4
–
6
. Here we determine the structure of the C9orf72–SM...
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Full title
Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD
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TN_cdi_proquest_miscellaneous_2437841285
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2437841285
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-2633-x
