SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation
SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
The SARS-CoV-2 non-structural protein 1 (Nsp1), also referred to as the host shutoff factor, suppresses host innate immune functions. By combining cryo-electron microscopy and biochemistry, we show that SARS-CoV-2 Nsp1 binds to the human 40S subunit in ribosomal complexes, including the 43S pre-initiation complex and the non-translating 80S ribosom...
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Full title
SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation
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TN_cdi_proquest_miscellaneous_2441606358
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2441606358
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-020-0511-8
