Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B
Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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CpG methylation by de novo DNA methyltransferases (DNMTs) 3A and 3B is essential for mammalian development and differentiation and is frequently dysregulated in cancer
1
. These two DNMTs preferentially bind to nucleosomes, yet cannot methylate the DNA wrapped around the nucleosome core
2
, and they favour the methylation of linker DNA...
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Full title
Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B
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TN_cdi_proquest_miscellaneous_2445974370
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2445974370
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-2747-1
