Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion
Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion
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Author / Creator
Yu, Yi-Ru , Imrichova, Hana , Wang, Haiping , Chao, Tung , Xiao, Zhengtao , Gao, Min , Rincon-Restrepo, Marcela , Franco, Fabien , Genolet, Raphael , Cheng, Wan-Chen , Jandus, Camilla , Coukos, George , Jiang, Yi-Fan , Locasale, Jason W. , Zippelius, Alfred , Liu, Pu-Ste , Tang, Li , Bock, Christoph , Vannini, Nicola and Ho, Ping-Chih
Publisher
New York: Nature Publishing Group US
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English
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Publisher
New York: Nature Publishing Group US
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Contents
The metabolic challenges present in tumors attenuate the metabolic fitness and antitumor activity of tumor-infiltrating T lymphocytes (TILs). However, it remains unclear whether persistent metabolic insufficiency can imprint permanent T cell dysfunction. We found that TILs accumulated depolarized mitochondria as a result of decreased mitophagy acti...
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Full title
Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion
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TN_cdi_proquest_miscellaneous_2448843056
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2448843056
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-020-0793-3
