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A mixture of chloromethylisothiazolinone and methylisothiazolinone impairs rat vascular smooth muscl...

A mixture of chloromethylisothiazolinone and methylisothiazolinone impairs rat vascular smooth muscl...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2452091858

A mixture of chloromethylisothiazolinone and methylisothiazolinone impairs rat vascular smooth muscle by depleting thiols and thereby elevating cytosolic Zn2+ and generating reactive oxygen species

About this item

Full title

A mixture of chloromethylisothiazolinone and methylisothiazolinone impairs rat vascular smooth muscle by depleting thiols and thereby elevating cytosolic Zn2+ and generating reactive oxygen species

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Journal title

Archives of toxicology, 2021-02, Vol.95 (2), p.541-556

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

More information

Scope and Contents

Contents

Chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) are biocidal preservatives and the active ingredients in Kathon CG, which contains ca. 1.5% mixture of CMIT and MIT at a ratio of 3:1 (CMIT/MIT). CMIT/MIT was misused as humidifier disinfectant products, which caused serious health problems in Korea. Here, the vascular effects of CM...

Alternative Titles

Full title

A mixture of chloromethylisothiazolinone and methylisothiazolinone impairs rat vascular smooth muscle by depleting thiols and thereby elevating cytosolic Zn2+ and generating reactive oxygen species

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2452091858

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2452091858

Other Identifiers

ISSN

0340-5761

E-ISSN

1432-0738

DOI

10.1007/s00204-020-02930-z

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