Mutations and mechanisms of WNT pathway tumour suppressors in cancer
Mutations and mechanisms of WNT pathway tumour suppressors in cancer
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Mutation-induced activation of WNT–β-catenin signalling is a frequent driver event in human cancer. Sustained WNT–β-catenin pathway activation endows cancer cells with sustained self-renewing growth properties and is associated with therapy resistance. In healthy adult stem cells, WNT pathway activity is carefully controlled by core pathway tumour...
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Full title
Mutations and mechanisms of WNT pathway tumour suppressors in cancer
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TN_cdi_proquest_miscellaneous_2454116174
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2454116174
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ISSN
1474-175X
E-ISSN
1474-1768
DOI
10.1038/s41568-020-00307-z
