Detection and impact of hysteresis when evaluating a drug’s QTc effect using concentration-QTc analy...
Detection and impact of hysteresis when evaluating a drug’s QTc effect using concentration-QTc analysis
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New York: Springer US
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Language
English
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New York: Springer US
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Early-phase studies quantifying the QTc prolongation potential for a new drug often use linear concentration-QTc (C-QTc) models, assuming no delay between plasma concentrations and QTc changes. However, that assumption is not always correct. The term “hysteresis” has been utilized to describe a time lag present between a measurable concentration an...
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Detection and impact of hysteresis when evaluating a drug’s QTc effect using concentration-QTc analysis
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TN_cdi_proquest_miscellaneous_2455835971
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2455835971
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ISSN
1567-567X
E-ISSN
1573-8744
DOI
10.1007/s10928-020-09725-w
