MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects
MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects
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Author / Creator
Verma, Vivek , Jafarzadeh, Nazli , Boi, Shannon , Kundu, Subhadip , Jiang, Zhinuo , Fan, Yiping , Lopez, Jose , Nandre, Rahul , Zeng, Peng , Alolaqi, Fatmah , Ahmad, Shamim , Gaur, Pankaj , Barry, Simon T. , Valge-Archer, Viia E. , Smith, Paul D. , Banchereau, Jacques , Mkrtichyan, Mikayel , Youngblood, Benjamin , Rodriguez, Paulo C. , Gupta, Seema and Khleif, Samir N.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Regenerative stem cell–like memory (T
SCM
) CD8
+
T cells persist longer and produce stronger effector functions. We found that MEK1/2 inhibition (MEKi) induces T
SCM
that have naive phenotype with self-renewability, enhanced multipotency and proliferative capacity. This is achieved by delaying cell division and enhancing mitochon...
Alternative Titles
Full title
MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects
Authors, Artists and Contributors
Author / Creator
Jafarzadeh, Nazli
Boi, Shannon
Kundu, Subhadip
Jiang, Zhinuo
Fan, Yiping
Lopez, Jose
Nandre, Rahul
Zeng, Peng
Alolaqi, Fatmah
Ahmad, Shamim
Gaur, Pankaj
Barry, Simon T.
Valge-Archer, Viia E.
Smith, Paul D.
Banchereau, Jacques
Mkrtichyan, Mikayel
Youngblood, Benjamin
Rodriguez, Paulo C.
Gupta, Seema
Khleif, Samir N.
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2464144427
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2464144427
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-020-00818-9
