Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction
Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Cryogenic electron microscopy (cryo-EM) is widely used to study biological macromolecules that comprise regions with disorder, flexibility or partial occupancy. For example, membrane proteins are often kept in solution with detergent micelles and lipid nanodiscs that are locally disordered. Such spatial variability negatively impacts computational...
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Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction
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TN_cdi_proquest_miscellaneous_2466036531
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2466036531
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ISSN
1548-7091
E-ISSN
1548-7105
DOI
10.1038/s41592-020-00990-8
