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Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis

Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2473400506

Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis

About this item

Full title

Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2021-02, Vol.590 (7847), p.612-617

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

In the adult hippocampus, synapses are constantly formed and eliminated
1
,
2
. However, the exact function of synapse elimination in the adult brain, and how it is regulated, are largely unknown. Here we show that astrocytic phagocytosis
3
is important for maintaining proper hippocampal synaptic connectivity and plasticity. By us...

Alternative Titles

Full title

Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2473400506

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2473400506

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-020-03060-3

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