Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopepti...
Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases
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London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Cyclic disulfide-rich peptides have attracted significant interest in drug development and biotechnology. Here, we describe a protocol for producing cyclic peptide precursors in
Pichia pastoris
that undergo in vitro enzymatic maturation into cyclic peptides using recombinant asparaginyl endopeptidases (AEPs). Peptide precursors are expressed...
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Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases
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TN_cdi_proquest_miscellaneous_2491073305
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2491073305
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ISSN
1754-2189
E-ISSN
1750-2799
DOI
10.1038/s41596-020-00483-0
