Coupled analysis of transcriptome and BCR mutations reveals role of OXPHOS in affinity maturation
Coupled analysis of transcriptome and BCR mutations reveals role of OXPHOS in affinity maturation
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Antigen-activated B cells diversify variable regions of B cell antigen receptors by somatic hypermutation in germinal centers (GCs). The positive selection of GC B cells that acquire high-affinity mutations enables antibody affinity maturation. In spite of considerable progress, the genomic states underlying this process remain to be elucidated. Si...
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Coupled analysis of transcriptome and BCR mutations reveals role of OXPHOS in affinity maturation
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TN_cdi_proquest_miscellaneous_2532245245
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2532245245
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-021-00936-y
