Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or re...
Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis
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Full title
Author / Creator
Vitanza, Nicholas A. , Johnson, Adam J. , Wilson, Ashley L. , Brown, Christopher , Yokoyama, Jason K. , Künkele, Annette , Chang, Cindy A. , Rawlings-Rhea, Stephanie , Huang, Wenjun , Seidel, Kristy , Albert, Catherine M. , Pinto, Navin , Gust, Juliane , Finn, Laura S. , Ojemann, Jeffrey G. , Wright, Jason , Orentas, Rimas J. , Baldwin, Michael , Gardner, Rebecca A. , Jensen, Michael C. and Park, Julie R.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Locoregional delivery of chimeric antigen receptor (CAR) T cells has resulted in objective responses in adults with glioblastoma, but the feasibility and tolerability of this approach is yet to be evaluated for pediatric central nervous system (CNS) tumors. Here we show that engineering of a medium-length CAR spacer enhances the therapeutic efficac...
Alternative Titles
Full title
Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis
Authors, Artists and Contributors
Author / Creator
Johnson, Adam J.
Wilson, Ashley L.
Brown, Christopher
Yokoyama, Jason K.
Künkele, Annette
Chang, Cindy A.
Rawlings-Rhea, Stephanie
Huang, Wenjun
Seidel, Kristy
Albert, Catherine M.
Pinto, Navin
Gust, Juliane
Finn, Laura S.
Ojemann, Jeffrey G.
Wright, Jason
Orentas, Rimas J.
Baldwin, Michael
Gardner, Rebecca A.
Jensen, Michael C.
Park, Julie R.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2551210498
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2551210498
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-021-01404-8