Log in to save to my catalogue

Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or re...

Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or re...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2551210498

Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis

About this item

Full title

Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis

Publisher

New York: Nature Publishing Group US

Journal title

Nature medicine, 2021-09, Vol.27 (9), p.1544-1552

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

Locoregional delivery of chimeric antigen receptor (CAR) T cells has resulted in objective responses in adults with glioblastoma, but the feasibility and tolerability of this approach is yet to be evaluated for pediatric central nervous system (CNS) tumors. Here we show that engineering of a medium-length CAR spacer enhances the therapeutic efficac...

Alternative Titles

Full title

Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2551210498

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2551210498

Other Identifiers

ISSN

1078-8956

E-ISSN

1546-170X

DOI

10.1038/s41591-021-01404-8

How to access this item