Enhancer reprogramming in PRC2-deficient malignant peripheral nerve sheath tumors induces a targetab...
Enhancer reprogramming in PRC2-deficient malignant peripheral nerve sheath tumors induces a targetable de-differentiated state
About this item
Full title
Author / Creator
Kochat, Veena , Raman, Ayush T. , Landers, Sharon M. , Tang, Ming , Schulz, Jonathan , Terranova, Christopher , Landry, Jace P. , Bhalla, Angela D. , Beird, Hannah C. , Wu, Chia-Chin , Jiang, Yingda , Mao, Xizeng , Lazcano, Rossana , Gite, Swati , Ingram, Davis R. , Yi, Min , Zhang, Jianhua , Keung, Emily Z. , Scally, Christopher P. , Roland, Christina L. , Hunt, Kelly K. , Feig, Barry W. , Futreal, P. Andrew , Hwu, Patrick , Wang, Wei-Lien , Lazar, Alexander J. , Slopis, John M. , Wilson-Robles, Heather , Wiener, Dominique J. , McCutcheon, Ian E. , Wustefeld-Janssens, Brandan , Rai, Kunal and Torres, Keila E.
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
Malignant peripheral nerve sheath tumors (MPNSTs) are soft tissue sarcomas that frequently harbor genetic alterations in polycomb repressor complex 2 (PRC2) components—
SUZ12
and
EED
. Here, we show that PRC2 loss confers a dedifferentiated early neural-crest phenotype which is exclusive to PRC2-mutant MPNSTs and not a feature of neurof...
Alternative Titles
Full title
Enhancer reprogramming in PRC2-deficient malignant peripheral nerve sheath tumors induces a targetable de-differentiated state
Authors, Artists and Contributors
Author / Creator
Raman, Ayush T.
Landers, Sharon M.
Tang, Ming
Schulz, Jonathan
Terranova, Christopher
Landry, Jace P.
Bhalla, Angela D.
Beird, Hannah C.
Wu, Chia-Chin
Jiang, Yingda
Mao, Xizeng
Lazcano, Rossana
Gite, Swati
Ingram, Davis R.
Yi, Min
Zhang, Jianhua
Keung, Emily Z.
Scally, Christopher P.
Roland, Christina L.
Hunt, Kelly K.
Feig, Barry W.
Futreal, P. Andrew
Hwu, Patrick
Wang, Wei-Lien
Lazar, Alexander J.
Slopis, John M.
Wilson-Robles, Heather
Wiener, Dominique J.
McCutcheon, Ian E.
Wustefeld-Janssens, Brandan
Rai, Kunal
Torres, Keila E.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2553525524
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2553525524
Other Identifiers
ISSN
0001-6322
E-ISSN
1432-0533
DOI
10.1007/s00401-021-02341-z
