This study investigated the anti‐inflammatory and antioxidant effects of hydroalcoholic extracts of mango peel and pulp on oxidative damage in a naproxen‐induced gastric injury rat model. The extracts were assessed for antioxidant activity (ABTS and FRAP methods), and the phenolic profile was investigated with UPLC‐QToF‐MSE. Gastric damage was evaluated in vivo by assessing the membrane lipid peroxidation (malondialdehyde (MDA) content), myeloperoxidase (MPO) enzyme activity, and glutathione (GSH) content. Mango peel and pulp contained high contents of bioactive compounds, particularly phenolics (69.50–5.287.70 mg gallic acid equivalents/100 g), carotenoids (651.30–665.50 μg/100 g), and vitamin C (21.59–108.19 mg/100 g). UPLC‐QToF‐MSE analysis identified 17 phenol compounds, including gallotannins, glycosylated flavonoids, and xanthone. The hydroalcoholic extracts of mango peel and pulp (LPe and LPu, respectively) significantly reduced the MPO activity and MDA content. In addition to preventing naproxen‐induced GSH decline, LPe (30 mg/kg) and LPu (10 mg/kg) restored its content to normal levels. LPe and LPu neutralized the oxidizing agents triggered by naproxen and reduced the severity of gastric lesions owing to their antioxidant properties.
Epidemiological studies have shown that products with antioxidant activity can be used as potential agents in the treatment and prevention of chronic inflammatory diseases, such as gastric ulcers. Our study showed the possibility of using mango extracts as antioxidants and gastroprotectants, opening a new perspective in which a cheap and abundant food and its industrial residues can be transformed into pharmacological alternatives or applied as adjuvants in the treatment of chronic inflammatory diseases induced by oxidative stress.