Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis
Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis
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Shinoda, Daisuke , Nakajima-Takagi, Yaeko , Oshima, Motohiko , Koide, Shuhei , Aoyama, Kazumasa , Saraya, Atsunori , Harada, Hironori , Rahmutulla, Bahityar , Kaneda, Atsushi , Yamaguchi, Kiyoshi , Furukawa, Yoichi , Koseki, Haruhiko , Shimoda, Kazuya , Tanaka, Tomoaki , Sashida, Goro and Iwama, Atsushi
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Insufficiency of polycomb repressive complex 2 (PRC2), which trimethylates histone H3 at lysine 27, is frequently found in primary myelofibrosis and promotes the development of JAK2V617F-induced myelofibrosis in mice by enhancing the production of dysplastic megakaryocytes. Polycomb group ring finger protein 1 (Pcgf1) is a component of PRC1.1, a no...
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Full title
Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis
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TN_cdi_proquest_miscellaneous_2571052089
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2571052089
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ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/s41375-021-01402-2
