Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell–substrate adhesion in c...
Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell–substrate adhesion in cancer cells and mechanosensitivity of cell proliferation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The actin cytoskeleton is the primary driver of cellular adhesion and mechanosensing due to its ability to generate force and sense the stiffness of the environment. At the cell’s leading edge, severing of the protruding Arp2/3 actin network generates a specific actin/tropomyosin (Tpm) filament population that controls lamellipodial persistence. Th...
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Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell–substrate adhesion in cancer cells and mechanosensitivity of cell proliferation
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TN_cdi_proquest_miscellaneous_2572526891
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2572526891
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ISSN
1476-1122
E-ISSN
1476-4660
DOI
10.1038/s41563-021-01087-z
