Structures of the human cholecystokinin receptors bound to agonists and antagonists
Structures of the human cholecystokinin receptors bound to agonists and antagonists
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Author / Creator
Zhang, Xuefeng , He, Chenglin , Wang, Mu , Zhou, Qingtong , Yang, Dehua , Zhu, Ya , Feng, Wenbo , Zhang, Hui , Dai, Antao , Chu, Xiaojing , Wang, Jia , Yang, Zhenlin , Jiang, Yi , Sensfuss, Ulrich , Tan, Qiuxiang , Han, Shuo , Reedtz-Runge, Steffen , Xu, H. Eric , Zhao, Suwen , Wang, Ming-Wei , Wu, Beili and Zhao, Qiang
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Cholecystokinin receptors, CCK
A
R and CCK
B
R, are important neurointestinal peptide hormone receptors and play a vital role in food intake and appetite regulation. Here, we report three crystal structures of the human CCK
A
R in complex with different ligands, including one peptide agonist and two small-molecule antagonists, as...
Alternative Titles
Full title
Structures of the human cholecystokinin receptors bound to agonists and antagonists
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TN_cdi_proquest_miscellaneous_2576651575
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2576651575
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-021-00866-8
