Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection
Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection
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Munnur, Deeksha , Teo, Qiwen , Eggermont, Denzel , Lee, Horace H. Y. , Thery, Fabien , Ho, Julian , van Leur, Sophie Wilhelmina , Ng, Wilson W. S. , Siu, Lewis Y. L. , Beling, Antje , Ploegh, Hidde , Pinto-Fernandez, Adan , Damianou, Andreas , Kessler, Benedikt , Impens, Francis , Mok, Chris Ka Pun and Sanyal, Sumana
Publisher
New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Ubiquitin-like protein ISG15 (interferon-stimulated gene 15) (ISG15) is a ubiquitin-like modifier induced during infections and involved in host defense mechanisms. Not surprisingly, many viruses encode deISGylating activities to antagonize its effect. Here we show that infection by Zika, SARS-CoV-2 and influenza viruses induce ISG15-modifying enzy...
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Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection
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TN_cdi_proquest_miscellaneous_2583443988
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2583443988
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-021-01035-8
