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Loss of function polymorphisms in SLCO1B1 (c.521T>C, rs4149056) and ABCG2 (c.421C>A, rs2231142) gene...

Loss of function polymorphisms in SLCO1B1 (c.521T>C, rs4149056) and ABCG2 (c.421C>A, rs2231142) gene...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2584017707

Loss of function polymorphisms in SLCO1B1 (c.521T>C, rs4149056) and ABCG2 (c.421C>A, rs2231142) genes are associated with adverse events of rosuvastatin: a case–control study

About this item

Full title

Loss of function polymorphisms in SLCO1B1 (c.521T>C, rs4149056) and ABCG2 (c.421C>A, rs2231142) genes are associated with adverse events of rosuvastatin: a case–control study

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Journal title

European journal of clinical pharmacology, 2022-02, Vol.78 (2), p.227-236

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

More information

Scope and Contents

Contents

Purpose
The study aims to evaluate relationship between polymorphisms associated with a reduced function of two transporter proteins resulting in increased exposure to rosuvastatin — organic anion transporter 1B1 (OATP1B1) (
SLCO1B1 c.521T
>
C
) and ATP binding cassette subfamily G member 2 (ABCG2) (
ABCG2 c.421C
>
A
) an...

Alternative Titles

Full title

Loss of function polymorphisms in SLCO1B1 (c.521T>C, rs4149056) and ABCG2 (c.421C>A, rs2231142) genes are associated with adverse events of rosuvastatin: a case–control study

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2584017707

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2584017707

Other Identifiers

ISSN

0031-6970

E-ISSN

1432-1041

DOI

10.1007/s00228-021-03233-7

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