Synonymous mutations reveal genome-wide levels of positive selection in healthy tissues
Synonymous mutations reveal genome-wide levels of positive selection in healthy tissues
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New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Genetic alterations under positive selection in healthy tissues have implications for cancer risk. However, total levels of positive selection across the genome remain unknown. Passenger mutations are influenced by all driver mutations, regardless of type or location in the genome. Therefore, the total number of passengers can be used to estimate t...
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Synonymous mutations reveal genome-wide levels of positive selection in healthy tissues
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TN_cdi_proquest_miscellaneous_2594291642
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2594291642
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-021-00957-1
