PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis
PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The accumulation of lipid peroxides is recognized as a determinant of the occurrence of ferroptosis. However, the sensors and amplifying process of lipid peroxidation linked to ferroptosis remain obscure. Here we identify PKCβII as a critical contributor of ferroptosis through independent genome-wide CRISPR–Cas9 and kinase inhibitor library screeni...
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PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis
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TN_cdi_proquest_miscellaneous_2620080586
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2620080586
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-021-00818-3
