Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3
Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
NLRP3 is an intracellular sensor protein that when activated by a broad spectrum of exogenous and endogenous stimuli leads to inflammasome formation and pyroptosis
1
,
2
. The conformational states of NLRP3 and the way antagonistic small molecules act at the molecular level remain poorly understood
2
,
3
. Here we report the...
Alternative Titles
Full title
Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2626009907
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2626009907
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-022-04467-w
