Genetic associations at regulatory phenotypes improve fine-mapping of causal variants for 12 immune-...
Genetic associations at regulatory phenotypes improve fine-mapping of causal variants for 12 immune-mediated diseases
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
The resolution of causal genetic variants informs understanding of disease biology. We used regulatory quantitative trait loci (QTLs) from the BLUEPRINT, GTEx and eQTLGen projects to fine-map putative causal variants for 12 immune-mediated diseases. We identify 340 unique loci that colocalize with high posterior probability (≥98%) with regulatory Q...
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Full title
Genetic associations at regulatory phenotypes improve fine-mapping of causal variants for 12 immune-mediated diseases
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TN_cdi_proquest_miscellaneous_2639224254
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2639224254
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-022-01025-y
