Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4
Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4
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Author / Creator
Xiao, Peng , Guo, Shengchao , Wen, Xin , He, Qing-Tao , Lin, Hui , Huang, Shen-Ming , Gou, Lu , Zhang, Chao , Yang, Zhao , Zhong, Ya-Ni , Yang, Chuan-Cheng , Li, Yu , Gong, Zheng , Tao, Xiao-Na , Yang, Zhi-Shuai , Lu, Yan , Li, Shao-Long , He, Jun-Yan , Wang, Chuanxin , Zhang, Lei , Kong, Liangliang , Sun, Jin-Peng and Yu, Xiao
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Adhesion G protein-coupled receptors (aGPCRs) constitute an evolutionarily ancient family of receptors that often undergo autoproteolysis to produce α and β subunits
1
–
3
. A tethered agonism mediated by the ‘Stachel sequence’ of the β subunit has been proposed to have central roles in aGPCR activation
4
–
6
. Here we prese...
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Full title
Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4
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Record Identifier
TN_cdi_proquest_miscellaneous_2650252000
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2650252000
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-022-04590-8
