Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-...
Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Brain development and function require uptake of essential omega-3 fatty acids in the form of lysophosphatidylcholine via major-facilitator superfamily transporter MFSD2A, a potential pharmaceutical target to modulate blood–brain barrier (BBB) permeability. MFSD2A is also the receptor of endogenous retroviral envelope syncytin-2 (SYNC2) in human pl...
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Full title
Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2
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TN_cdi_proquest_miscellaneous_2678425911
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2678425911
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-022-00786-8
