APR-246 triggers ferritinophagy and ferroptosis of diffuse large B-cell lymphoma cells with distinct...
APR-246 triggers ferritinophagy and ferroptosis of diffuse large B-cell lymphoma cells with distinct TP53 mutations
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Author / Creator
Hong, Yuheng , Ren, Tianyuan , Wang, Xiaoxuan , Liu, Xia , Fei, Yue , Meng, Shen , Han, Xu , Sun, Cong , Shen, Hongru , Li, Lanfang , Qiu, Lihua , Qian, Zhengzi , Zhou, Shiyong , Zhang, Huilai and Wang, Xianhuo
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
TP53 mutations correlate with inferior survival in many cancers. APR-246 is a compound to shift mutant p53 and exhibits anti-cancer effects. Among its effects, APR-246 facilitates the binding of restored p53 mutants to target genes and their transcription. A set of 2464 DLBCL cases from multiple cohorts including our center, was integrated to ident...
Alternative Titles
Full title
APR-246 triggers ferritinophagy and ferroptosis of diffuse large B-cell lymphoma cells with distinct TP53 mutations
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Record Identifier
TN_cdi_proquest_miscellaneous_2691052565
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2691052565
Other Identifiers
ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/s41375-022-01634-w
