O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1
O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1
About this item
Full title
Author / Creator
Zhu, Qiang , Zhou, Hong , Wu, Liming , Lai, Zhenyuan , Geng, Didi , Yang, Weiwei , Zhang, Jie , Fan, Zhiya , Qin, Weijie , Wang, Yong , Zhou, Ruhong and Yi, Wen
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Oncogenic Kras-activated pancreatic ductal adenocarcinoma (PDAC) cells highly rely on an unconventional glutamine catabolic pathway to sustain cell growth. However, little is known about how this pathway is regulated. Here we demonstrate that Kras mutation induces cellular
O
-linked β-
N
-acetylglucosamine (
O
-GlcNAc), a prevalen...
Alternative Titles
Full title
O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2694961091
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2694961091
Other Identifiers
ISSN
1552-4450,1552-4469
E-ISSN
1552-4469
DOI
10.1038/s41589-022-01085-5
