PBRM1, SETD2 and BAP1 — the trinity of 3p in clear cell renal cell carcinoma
PBRM1, SETD2 and BAP1 — the trinity of 3p in clear cell renal cell carcinoma
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Biallelic inactivation of the tumour suppressor gene Von Hippel–Lindau (
VHL
) occurs in the vast majority of clear cell renal cell carcinoma (ccRCC) instances, disrupting cellular oxygen-sensing mechanisms to yield a state of persistent pseudo-hypoxia, defined as a continued hypoxic response despite the presence of adequate oxygen levels. Ho...
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Full title
PBRM1, SETD2 and BAP1 — the trinity of 3p in clear cell renal cell carcinoma
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TN_cdi_proquest_miscellaneous_2725650957
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2725650957
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ISSN
1759-4812
E-ISSN
1759-4820
DOI
10.1038/s41585-022-00659-1
