Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base e...
Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing
About this item
Full title
Author / Creator
Chen, Liang , Zhu, Biyun , Ru, Gaomeng , Meng, Haowei , Yan, Yongchang , Hong, Mengjia , Zhang, Dan , Luan, Changming , Zhang, Shun , Wu, Hao , Gao, Hongyi , Bai, Sijia , Li, Changqing , Ding, Ruoyi , Xue, Niannian , Lei, Zhixin , Chen, Yuting , Guan, Yuting , Siwko, Stefan , Cheng, Yiyun , Song, Gaojie , Wang, Liren , Yi, Chengqi , Liu, Mingyao and Li, Dali
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Cytosine base editors (CBEs) efficiently generate precise C·G-to-T·A base conversions, but the activation-induced cytidine deaminase/apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (AID/APOBEC) protein family deaminase component induces considerable off-target effects and indels. To explore unnatural cytosine deaminases, we repurpos...
Alternative Titles
Full title
Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing
Authors, Artists and Contributors
Author / Creator
Zhu, Biyun
Ru, Gaomeng
Meng, Haowei
Yan, Yongchang
Hong, Mengjia
Zhang, Dan
Luan, Changming
Zhang, Shun
Wu, Hao
Gao, Hongyi
Bai, Sijia
Li, Changqing
Ding, Ruoyi
Xue, Niannian
Lei, Zhixin
Chen, Yuting
Guan, Yuting
Siwko, Stefan
Cheng, Yiyun
Song, Gaojie
Wang, Liren
Yi, Chengqi
Liu, Mingyao
Li, Dali
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2735893634
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2735893634
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/s41587-022-01532-7
