Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
CD8
+
T cells are critical for elimination of cancer cells. Factors within the tumor microenvironment (TME) can drive these cells to a hypofunctional state known as exhaustion. The most terminally exhausted T (tT
ex
) cells are resistant to checkpoint blockade immunotherapy and might instead limit immunotherapeutic efficacy. Here we sho...
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Full title
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity
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Record Identifier
TN_cdi_proquest_miscellaneous_2757160002
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2757160002
Other Identifiers
ISSN
1529-2908,1529-2916
E-ISSN
1529-2916
DOI
10.1038/s41590-022-01379-9
