Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising...
Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators
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Publisher
England: Taylor & Francis
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Language
English
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Publisher
England: Taylor & Francis
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In this research, two novel series of dibenzo[b,f]azepines (14 candidates) were designed and synthesised based on the rigidification principle and following the reported doxorubicin's pharmacophoric features. The anti-proliferative activity was evaluated at the NCI against a panel of 60 cancer cell lines. Further, the promising candidates (5a-g) we...
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Full title
Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators
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TN_cdi_proquest_miscellaneous_2764441756
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2764441756
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ISSN
1475-6366
E-ISSN
1475-6374
DOI
10.1080/14756366.2022.2157825
