Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation
Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation
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Author / Creator
Chen, Da-Yuan , Chin, Chue Vin , Kenney, Devin , Tavares, Alexander H. , Khan, Nazimuddin , Conway, Hasahn L. , Liu, GuanQun , Choudhary, Manish C. , Gertje, Hans P. , O’Connell, Aoife K. , Adams, Scott , Kotton, Darrell N. , Herrmann, Alexandra , Ensser, Armin , Connor, John H. , Bosmann, Markus , Li, Jonathan Z. , Gack, Michaela U. , Baker, Susan C. , Kirchdoerfer, Robert N. , Kataria, Yachana , Crossland, Nicholas A. , Douam, Florian and Saeed, Mohsan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The SARS-CoV-2 Omicron variant is more immune evasive and less virulent than other major viral variants that have so far been recognized
1
–
12
. The Omicron spike (S) protein, which has an unusually large number of mutations, is considered to be the main driver of these phenotypes. Here we generated chimeric recombinant SARS-CoV-2 enco...
Alternative Titles
Full title
Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation
Authors, Artists and Contributors
Author / Creator
Chin, Chue Vin
Kenney, Devin
Tavares, Alexander H.
Khan, Nazimuddin
Conway, Hasahn L.
Liu, GuanQun
Choudhary, Manish C.
Gertje, Hans P.
O’Connell, Aoife K.
Adams, Scott
Kotton, Darrell N.
Herrmann, Alexandra
Ensser, Armin
Connor, John H.
Bosmann, Markus
Li, Jonathan Z.
Gack, Michaela U.
Baker, Susan C.
Kirchdoerfer, Robert N.
Kataria, Yachana
Crossland, Nicholas A.
Douam, Florian
Saeed, Mohsan
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2765073175
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2765073175
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-023-05697-2
