Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia...
Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials
About this item
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Author / Creator
Yap, Timothy A. , Daver, Naval , Mahendra, Mikhila , Zhang, Jixiang , Kamiya-Matsuoka, Carlos , Meric-Bernstam, Funda , Kantarjian, Hagop M. , Ravandi, Farhad , Collins, Meghan E. , Francesco, Maria Emilia Di , Dumbrava, Ecaterina E. , Fu, Siqing , Gao, Sisi , Gay, Jason P. , Gera, Sonal , Han, Jing , Hong, David S. , Jabbour, Elias J. , Ju, Zhenlin , Karp, Daniel D. , Lodi, Alessia , Molina, Jennifer R. , Baran, Natalia , Naing, Aung , Ohanian, Maro , Pant, Shubham , Pemmaraju, Naveen , Bose, Prithviraj , Piha-Paul, Sarina A. , Rodon, Jordi , Salguero, Carolina , Sasaki, Koji , Singh, Anand K. , Subbiah, Vivek , Tsimberidou, Apostolia M. , Xu, Quanyun A. , Yilmaz, Musa , Zhang, Qi , Li, Yuan , Bristow, Christopher A. , Bhattacharjee, Meenakshi B. , Tiziani, Stefano , Heffernan, Timothy P. , Vellano, Christopher P. , Jones, Philip , Heijnen, Cobi J. , Kavelaars, Annemieke , Marszalek, Joseph R. and Konopleva, Marina
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Although targeting oxidative phosphorylation (OXPHOS) is a rational anticancer strategy, clinical benefit with OXPHOS inhibitors has yet to be achieved. Here we advanced IACS-010759, a highly potent and selective small-molecule complex I inhibitor, into two dose-escalation phase I trials in patients with relapsed/refractory acute myeloid leukemia (...
Alternative Titles
Full title
Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials
Authors, Artists and Contributors
Author / Creator
Daver, Naval
Mahendra, Mikhila
Zhang, Jixiang
Kamiya-Matsuoka, Carlos
Meric-Bernstam, Funda
Kantarjian, Hagop M.
Ravandi, Farhad
Collins, Meghan E.
Francesco, Maria Emilia Di
Dumbrava, Ecaterina E.
Fu, Siqing
Gao, Sisi
Gay, Jason P.
Gera, Sonal
Han, Jing
Hong, David S.
Jabbour, Elias J.
Ju, Zhenlin
Karp, Daniel D.
Lodi, Alessia
Molina, Jennifer R.
Baran, Natalia
Naing, Aung
Ohanian, Maro
Pant, Shubham
Pemmaraju, Naveen
Bose, Prithviraj
Piha-Paul, Sarina A.
Rodon, Jordi
Salguero, Carolina
Sasaki, Koji
Singh, Anand K.
Subbiah, Vivek
Tsimberidou, Apostolia M.
Xu, Quanyun A.
Yilmaz, Musa
Zhang, Qi
Li, Yuan
Bristow, Christopher A.
Bhattacharjee, Meenakshi B.
Tiziani, Stefano
Heffernan, Timothy P.
Vellano, Christopher P.
Jones, Philip
Heijnen, Cobi J.
Kavelaars, Annemieke
Marszalek, Joseph R.
Konopleva, Marina
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2768239119
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2768239119
Other Identifiers
ISSN
1078-8956,1546-170X
E-ISSN
1546-170X
DOI
10.1038/s41591-022-02103-8
