Reducing affinity as a strategy to boost immunomodulatory antibody agonism
Reducing affinity as a strategy to boost immunomodulatory antibody agonism
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Antibody responses during infection and vaccination typically undergo affinity maturation to achieve high-affinity binding for efficient neutralization of pathogens
1
,
2
. Similarly, high affinity is routinely the goal for therapeutic antibody generation. However, in contrast to naturally occurring or direct-targeting therapeutic antib...
Alternative Titles
Full title
Reducing affinity as a strategy to boost immunomodulatory antibody agonism
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TN_cdi_proquest_miscellaneous_2771940169
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2771940169
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-022-05673-2
