TGF-β1 induced activations of Smad2 and miRNAs inhibit SF-1- and LRH-1-dependent CYP19 expression in...
TGF-β1 induced activations of Smad2 and miRNAs inhibit SF-1- and LRH-1-dependent CYP19 expression in rat Leydig cells
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Author / Creator
Ma, Binfang , Qiao, Huilian , Guo, Ying , Wei, Jinhua , Yang, Qianqian , Feng, Xiao and Li, Zhen
Publisher
United States: Society for the Study of Reproduction
Journal title
Language
English
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Publisher
United States: Society for the Study of Reproduction
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Contents
P450 aromatase, encoded by the Cyp19 gene, catalyzes the synthesis of estrogen, which is crucial for mammalian germ cell differentiation. We have previously shown that transforming growth factor beta 1 (TGF-β1) attenuated the accumulation of steroidogenic factor-1 (SF-1) and liver receptor homolog-1 (LRH-1) and eventually reduced the transcription...
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Full title
TGF-β1 induced activations of Smad2 and miRNAs inhibit SF-1- and LRH-1-dependent CYP19 expression in rat Leydig cells
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Record Identifier
TN_cdi_proquest_miscellaneous_2781620690
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2781620690
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ISSN
0006-3363
E-ISSN
1529-7268
DOI
10.1093/biolre/ioad025
